More importantly, the observed increased expression of NLRP3 inflammasome, membrane GSDMD-N, as well as secretion of IL-1β and IL-18 could be significantly suppressed by Lycium barbarum polysaccharides (LBP) treatment, accompanied by a noticeable morphological recovery, suggesting a protective effect of LBP on an AMD in vitro model by suppressing pyroptosis [53]. Here, IL18 is linked to age-related macular degeneration.