Despite the low correlation (0.177) and large number of observed associations that may influence this observation towards significance, there is a change between a negative relationship between leptin and FGFR1 mRNA in normal tissue (−0.27) to a positive relationship between average leptin mRNA and FGFR1 mRNA in breast cancer tissue (0.16). The gene discussed is FGFR1; the disease is breast cancer.