Mitochondria-localized EGFR associates with c-Src at the mitochondrial inner membrane to phosphorylate cytochrome c oxidase subunit II (COXII), a component of the complex IV of the mitochondrial electron transport system; the interaction leads to inhibition of the COXII activity and to a reduction in ATP levels in breast cancer cells [26]. This evidence concerns the gene EGFR and breast cancer.