Next we examined if the mere 7-fold plasma concentration difference between IDH1/2 mutated and WT AML patients was due to differential expression of D-2-hydroxyglutarate dehydrogenase (D2HGDH; EC 1.1.99.39), which catalyzes the reverse reaction of 2R-HG to 2-OG. This evidence concerns the gene D2HGDH and acute myeloid leukemia.