The cellular export of 2R-HG might be expected to be elicited by the organic ion transporters 1 and 3 (OAT1 and OAT3, encoded by SLC22A6 and SLC22A8, respectively), which mediate the cellular efflux of 2-OG [52], but the occurrence of these transporters in AML cells or their transport of 2R-HG have not been reported. The gene discussed is SLC22A8; the disease is acute myeloid leukemia.