To date, the expression of D2HGDH in AML has not been reported, but as with HNSCC, it is possible that a high expression D2HGDH phenotype exists, which, if associated with IDH1/2, might explain the meager 7-fold difference in median plasma 2R-HG between mutated and WT IDH. Here, IDH1 is linked to acute myeloid leukemia.