The serine phosphorylation of IRS-1 blunts the activation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway, resulting in a reduction in glucose transporter 4 (GLUT4) translocation and glucose uptake in the skeletal muscle, which causes insulin resistance and hyperglycemia [9]. The gene discussed is AKT1; the disease is Insulin resistance.