In this context, it will be interesting to analyze the rate of MGRN1 mutations in melanoma families without mutations in known susceptibility genes such as CDKN2A, CDK4, BAP1, TERT, POT1, ACD, TERF2IP, and MITF. Interestingly, mutations in these genes are only found in 30–50% of melanoma families [61]. This evidence concerns the gene CDK4 and melanoma.