Indeed, its expression is increased at the mRNA level in the human frontal cortex of depression tissues [65] and, at the protein level, CaMKIIβ is significantly upregulated in the lateral habenula (nucleus that has emerged as a key brain region in aversive behaviors and the pathophysiology of depression) of animal models of depression and down-regulated by antidepressants [68]. The gene discussed is CAMK2B; the disease is major depressive disorder.