In line with previous reports that showed co-amplification of c-MET and ERBB pathways and their role in metastatic BC [24,56,57], we observed the higher expression of c-MET and ERBB1 receptors in ERBB2+ brain-seeking SKBrM3 cells as compared to its parental cell line, and in organoids derived from ERBB2-Tg mouse. The gene discussed is ERBB2; the disease is breast cancer.