In a mouse AD model, apigenin promoted the production of neurotrophic factors and the activity of SOD and glutathione peroxidase (GPx) and prevented Aβ from fibrillation and aggregation by downregulating beta-site amyloid-protein precursor cleaving enzyme (beta-secretase-1; BACE-1) [63]. The gene discussed is BACE1; the disease is Alzheimer disease.