Furthermore, surviving T cells are functionally exhausted [1] and an increase in numerous inflammatory factors’ levels, including several interleukins (IL-2, IL-6, IL-7, and IL-10), tumor necrosis factor-α (TNF-α), granulocyte colony-stimulating factor (GCSF), macrophage inflammatory protein 1-α (MIP-1α), monocyte chemoattractant protein-1 (MCP-1), and 10 kD interferon gamma-induced protein (IP-10), is observed in patients with severe infection. The gene discussed is TNF; the disease is infection.