Elucidation of the factors that more accurately determine oral cancer responsiveness, such as CD44, MMP-2, MMP-9, and hyaluronidase expression, may be needed to allow oral healthcare researchers and clinicians to more accurately assess and treat oral cancers with the most efficient and effective means of treatment that may include combination therapy with hyaluronic acid. The gene discussed is CD44; the disease is lip and oral cavity carcinoma.