In a model of allergic asthma, McAlees et al showed that CD4+ T cell subsets respond differentially to PD-1/PD-L1 blockade: overall regulation of CD4+ T cell responses by CPIs were complicated and strongly varied from strength of the TCR signaling and the initial TH1/TH2 status of the cell [51]. This evidence concerns the gene CD4 and allergic asthma.