Proteomics analysis of isolated EVs revealed a more proinflammatory phenotype in the “stroke EVs”, while coincubation with THP-1 monocyte-derived macrophages induced elevated mRNA expression of proinflammatory cytokines TNFα, IL-1β and chemokines CXCL-1 and CCL-2 [51]. The gene discussed is IL1B; the disease is Stroke.