SOD1 and amyotrophic lateral sclerosis: In multiple in-vivo studies on ALS, edaravone was capable of suppressing the nitration of tyrosine residues, attenuating motor decline and muscle weakness, reducing the abnormal disposition of SOD1 in the spinal cord, preserving motor neurons, decreasing denervation atrophy, and decreasing motor neuron degeneration [59,60,61].