A chemical compound, GS-444217, that specifically inhibit ASK1 (Apoptosis signal-regulating kinase 1), a protein kinase upstream of JNK and p38, has been reported to reduce liver fibrosis in a mouse model with a Nlrp3 (NLR family pyrin domain containing 3) loss-of-function mutation [28]. Here, MAP3K5 is linked to Hepatic fibrosis.