LAMP2 and Danon disease: Additional clinical manifestations include retinal disease,[3, 4, 5] hepatic disease,[6, 7] and pulmonary disease.[8] Furthermore, studies in LAMP-2 knockout mice have shown that many organs are affected, including the kidneys, pancreas, small intestine, thymus, and spleen.[6] At present, treatment interventions for Danon disease are mainly limited to the prevention of sudden death and heart failure through cardioverter defibrillator (ICD) implantation and heart transplantation.