Its primary genetic defect, a mutation in the LAMP-2 gene, disrupts autophagy, leading to impaired fusion of lysosomes to autophagosomes, and the biogenesis of lysosomes.[7] However, the exact function of the LAMP2 and the mechanisms by which LAMP2 deficiency causes Danon disease are not well understood.[8] Because Danon disease has an X-linked mode of inheritance, clinical symptoms appear earlier and are more severe in male patients. Here, LAMP2 is linked to Danon disease.