Neuron-specific enolase (NSE) can be of value in the diagnosis of small cell lung cancer, neuroendocrine tumors, all stages of neuroblastoma, melanoma, seminoma, renal cell carcinoma, Merkel cell tumor, carcinoid tumors, dysgerminomas and immature teratomas, malignant pheochromocytoma, Guillain-Barré syndrome, and Creutzfeldt-Jakob disease.[3] In addition, NSE might be utilized as a prognostic and therapeutic biomarker for neuroinflammation, neurodegeneration, and neuroprotection in spinal cord injury as well as neurodegenerative diseases.[4]. The gene discussed is ENO2; the disease is malignant adrenal gland pheochromocytoma.