Many literature reports believe that EA has a unique clinical effect on insomnia.[24, 25, 26] Studies have found that EA can alleviate the abnormal excitement of the sympathetic nerve epithelial medulla system of insomnia rats, thereby effectively treating insomnia.[27] Not only that, EA can also regulate the balance of neurotransmitters in the brain, such as GABA and Glu, the 2 most crucial amino acid neurotransmitters involved in sleep regulation.[28] In addition, EA can also reduce the levels of IL-1β, IL-2, and TNF-α in the hippocampus of the brain, thereby improving sleep quality.[29]. This evidence concerns the gene TNF and insomnia.