IGFBP2 and nervous system disorder: And among the patients beyond 1 year (49/56), 90% presented speech delay, 67% showed behavioral and neurological disorders such as ataxia, dyspraxia, hypotonia, obsessive-complusive disorder, and 25% showed seizures.[14] All these studies suggested that CNVs in BP1-BP2 may increase susceptibility to neuropsychiatric or neurodevelopmental disorders.