Third, in addition to the factors described in this study, other factors including the presence of the polymorphism Gln233Arg in the leptin receptor of the Mexican population and its association with hemodynamic and metabolic disturbances related to obesity,[60] the increased triglyceride levels in blood and altered propionic and butyric acid concentrations in stool samples of overweight and obese Mexican children,[61] and the rising obesogenic environment found in México,[62, 63] need to be taken into account when developing policies to prevent chronic diseases such as obesity. This evidence concerns the gene LEPR and obesity due to melanocortin 4 receptor deficiency.