In addition to the regulation of metabolism, nesfatin-1 also participated in cardiovascular actions and gastric mobility, stress, and reproduction.[3, 19, 20] Recent reports describe nesfatin-1 as molecules with neuroprotective property that relieve oxidative stress.[21] The excess of GH production in patients with acromegaly could lead to diabetes which obesity and oxidative stress are linked.[12, 22, 23, 24]. Here, NUCB2 is linked to diabetes mellitus.