Finally, we observed an increased level of both serum GH level (37.1 ± 9.44 ng/mL vs 1.12 ± 0.33 ng/mL, P = .000) and nesfatin-1 level (1.96 ± 0.56 vs 0.61 ± 0.10 ng/mL, P = .004) in the acromegaly group (Table 1). The gene discussed is NUCB2; the disease is acromegaly.