However, insoluble DF can accelerate the transport speed of food in the digestive tube, thus rapidly producing PYY3–36.[15] Pyy3–36 is a gastrointestinal hormone that suppresses appetite and binds to receptors in the hypothalamus to produce a sense of satiety.[16] Insoluble DF also absorbs toxic substances in food to prevent constipation and diverticulitis,. The gene discussed is PYY3; the disease is Colonic diverticula.