TLR4/MyD88/NF-κB signaling-induced inflammatory cytokines have also been linked to autophagy in many kinds of cells and organs including the placenta.[47, 48, 49] Shi-Fang Z et al demonstrated that ATG7 has proangiogenic activity in brain angiogenesis which is mediated by IL-6 production in a NF-κB-dependent manner.[13] The number of villi in the placental tissue of the GDM group increased, and the increase in vascular density was observed in our research. Here, ATG7 is linked to gestational diabetes.