TLR4/MyD88/NF-κB signaling-induced inflammatory cytokines have also been linked to autophagy in many kinds of cells and organs including the placenta.[47, 48, 49] Shi-Fang Z et al demonstrated that ATG7 has proangiogenic activity in brain angiogenesis which is mediated by IL-6 production in a NF-κB-dependent manner.[13] The number of villi in the placental tissue of the GDM group increased, and the increase in vascular density was observed in our research. The gene discussed is TLR4; the disease is gestational diabetes.