Activation of NF-κB must be dissociated and degraded from the NF-κB complex by IKB, exposing the nuclear localization sequence of NF-κB, then combined with a specific KB sequence such as p65.[42] Through research we found significant activation of IKBα and NF-κB p65 in the placenta of the GDM group. The gene discussed is NFKBIA; the disease is gestational diabetes.