PELI1 and nervous system disorder: We and others have previously revealed that the E3 ubiquitin ligase Pellino 1 (Peli1) is expressed in many kinds of neural cells in murine brain, with the highest expression level in the microglia [26], implying a nonredundant function of Peli1 in central nervous system (CNS) to modulate microglia-related neurological diseases.