Karadeniz et al. [22] evaluated the -174 G>C polymorphism of the IL-6 gene in T2DM with diabetic nephropathy in 43 cases of T2DM and 43 cases of T2DM with diabetic nephropathy and 340 healthy normal controls, the result of which showed that the frequency of the polymorphic G allele was 83.9% in diabetic patients with nephropathy versus 70.9% in those without nephropathy (P=0.039), the author suggested that the -174 G>C polymorphism of the IL-6 gene might be an independent risk factor for diabetic nephropathy in Turkish T2DM. This evidence concerns the gene IL6 and type 2 diabetes mellitus.