In order to further conform the roles of IL-6 rs1800795 in the predication the risk of diabetic microvascular complications in T2DM, we conducted here a meta-analysis of eligible case–control studies, the association between rs1800795 polymorphism in IL-6 gene and risk susceptibility to diabetic microvascular complications of T2DM under five genetic models was assessed. Here, IL6 is linked to complication.