Although MYCN depletion was much more pronounced in MYCN-amplified NB (Supplemental Figure 6B), depletion of Myc-driven housekeeping gene expression was also consistently observed in non–MYCN-amplified NB (Figure 3I and Supplemental Figure 6, A–E), suggesting that irrespective of MYCN amplification status, CDK9 inhibition targets canonical Myc target gene signatures associated with growth and biogenesis. The gene discussed is MYCN; the disease is neuroblastoma.