CYC065 induced significant tumor growth inhibition and increased overall survival in mice carrying MYCN-amplified Kelly NB tumor xenografts, but had weaker effects against non–MYCN-expressing SK-N-AS NB tumor xenografts (Figure 6, A and B), consistent with the modest effect on c-MYC levels (Supplemental Figure 8F). This evidence concerns the gene MYCN and neuroblastoma.