MYC and neuroblastoma: Although Myc deregulation leads to a global increase in cellular mRNA in an oncogenic context, transformation driven by Myc in neuroblastoma (NB), a developmental tumor of neural crest origin, is associated with selective (and enhancer dependent) upregulation of a limited set of lineage-related genes, expression of which normally constitutes a transcriptomic core regulatory circuit (CRC) that underlies neural identity and deregulation of which drives growth and proliferation of these tumors (10–12).