MYC and neuroblastoma: Although MYCN depletion was much more pronounced in MYCN-amplified NB (Supplemental Figure 6B), depletion of Myc-driven housekeeping gene expression was also consistently observed in non–MYCN-amplified NB (Figure 3I and Supplemental Figure 6, A–E), suggesting that irrespective of MYCN amplification status, CDK9 inhibition targets canonical Myc target gene signatures associated with growth and biogenesis.