In Endocrine system, 1‐III‐1 suffered from decreased ejaculatory function and erectile dysfunction, the sexual hormone and GnRH exciting test indicated hypogonadotropic hypogonadism (before GnRH irritation: FSH 0.43 IU/L, LH 0.51 IU/L; after GnRH irritation: FSH 0.57 IU/L, LH 0.76 IU/L). This evidence concerns the gene GNRH1 and hypogonadotropic hypogonadism.