However, it was reported that although AUF1 could degrade CyclinD1 mRNA, the expression of CyclinD1 was still decreased when the AUF1 expression was knocked down18 and transgenic mice that overexpressed p37 AUF1 developed undifferentiated sarcomas with the concomitant overexpression of CyclinD1.22 This evidence concerns the gene CCND1 and sarcoma.