The R453 residue in MYH7 is analogous to the R673 residue targeted for mutation here in the zebrafish gene, smyhc1. Prior work has modeled the MYH7 R453C variant in mice, demonstrating that treatment with cardiac specific myosin inhibitors, including the small molecule MYK‐461, reduces ventricular hypertrophy, cardiomyocyte disarray, and profibrotic gene expression that are hallmarks of human hypertrophic cardiomyopathy (Green et al, 2016). Here, MYH7 is linked to cardiac hypertrophy.