SMPD1 and anterior segment dysgenesis: To determine whether the reduction in CB1 protein levels observed in the Purkinje neurons of the ASM‐KO mouse also occurred in patients, we gained access to fixed tissue from the cerebellum of a 3‐year‐old child affected by infantile neurovisceral ASMD and compared CB1 levels in the calbindin‐positive cells by immunofluorescence with an age‐matched non‐affected child.