SNORD115 and anxiety disorder: Because altered HTR2C signaling, including abnormal RNA editing, is linked to anxiety disorders and depressive states (Chagraoui et al., 2016; Heisler et al., 2007; Mombereau et al., 2010; Spoida et al., 2014), we first subjected a cohort of 8–12 week-old Snord115-deficient and WT mice to the open field (OF) test.