SNORD115 and Prader-Willi syndrome: Altogether, defective post-transcriptional processing of HTR2C pre-mRNA - and thus impaired HTR2C pathway - has been surmised to account for overeating and anxio-depressive phenotypes frequently encountered in PWS patients (Cavaillé, 2017; Stamm et al., 2017), although the loss of SNORD115 is unlikely to be sufficient to elicit PWS (Bürger et al., 2002; Runte et al., 2005).