To further identify the mechanism of TYROBP expression in the development of ccRCC, we analyzed the connection of TYROBP expression levels with immune cells infiltration, and we discovered that TYROBP is related to high infiltration rate in immune cells, including B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells. This evidence concerns the gene CD4 and nonpapillary renal cell carcinoma.