HCST and neoplasm: We found that TYROBP and genes that interact with TYROBP are differentially expressed in KIRC by downloading the relevant data of KIRC in the TCGA database, including 72 normal samples and 539 tumor samples, where the expressions of NCR2, KLRD1, SIGLEC14, HCST, TREM2, TYROBP, TREM1, CD300E, CLEC5A and CD300LB are higher in tumors than in normal kidney tissue, and the expression of SYK is lower in tumors than in normal kidney tissue (Fig. 7H).