We found that HRG, FABP1, ALDOB, PCK1, HAO2, CASR, PLG and HMGCS2 were down‐regulated in ccRCC in comparison with normal kidney tissues (Fig. 4A), and these eight genes were exposed to poor survival rate (Fig. 4B). The gene discussed is HRG; the disease is nonpapillary renal cell carcinoma.