From the earlier results, it can be inferred that HRG, FABP1, ALDOB, PCK1, HAO2, CASR, PLG and HMGCS2 may be the tumor suppressor genes of ccRCC, whereas SERPINE1 and TYROBP may be the oncogenes of ccRCC. This evidence concerns the gene HMGCS2 and nonpapillary renal cell carcinoma.