The survival analysis showed that eight down‐regulated hub genes (HRG, FABP1, ALDOB, PCK1, HAO2, CASR, PLG, and HMGCS2) and two up‐regulated hub genes (SERPINE1 and TYROBP) may be the key genes in ccRCC. The gene discussed is SERPINE1; the disease is nonpapillary renal cell carcinoma.