From the earlier results, it can be inferred that HRG, FABP1, ALDOB, PCK1, HAO2, CASR, PLG and HMGCS2 may be the tumor suppressor genes of ccRCC, whereas SERPINE1 and TYROBP may be the oncogenes of ccRCC. The gene discussed is SERPINE1; the disease is nonpapillary renal cell carcinoma.