The survival analysis showed that eight down‐regulated hub genes (HRG, FABP1, ALDOB, PCK1, HAO2, CASR, PLG, and HMGCS2) and two up‐regulated hub genes (SERPINE1 and TYROBP) may be the key genes in ccRCC. This evidence concerns the gene HAO2 and nonpapillary renal cell carcinoma.