Because immunotherapy is currently a hot topic in renal cell carcinoma research, we conducted an immunological correlation analysis of TYROBP in the TIMER website(https://icbi.i‐med.ac.at/software/timiner/timiner.shtml), and we were surprised to discover that TYROBP has an intimated connection with immune cells infiltration and classic immune checkpoint gene (PD‐1, CTLA‐4). Here, TYROBP is linked to hereditary clear cell renal cell carcinoma.