NGF and diabetic neuropathy: During the development of diabetic neuropathy, neutrophils and macrophages can be recruited and activated by numerous factors (selectins, leukotriene B4, and nerve growth factor), resulting in the significant production of pronociceptive mediators such as lipoxygenase, superoxide, cyclooxygenase, nitric oxide (NO), proinflammatory cytokines (TNF-α, IL-1β, and IL-6), NGF, prostaglandins, and chemokines [58, 59].