Inflammation plays a major role in disc degeneration, as proinflammatory cytokines (ie, tumor necrosis factor alpha [TNF‐α], interleukin 1 beta [IL‐1β], interleukin 6 [IL‐6], interleukin 8 [IL‐8], interleukin 17 [IL‐17], and interferon gamma [IFN‐γ]) induce and trigger discal ECM breakdown and accelerated catabolism by stimulation of catabolic enzymes such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS).6, 17, 18, 19, 20. This evidence concerns the gene IFNG and intervertebral disk degenerative disorder.