PIK3CA and adenocarcinoma: Interestingly, the frequency and distribution of GAs identified in this cohort of patients are similar and distinct from mutational patterns described in the more common HPV-related cervical cancer histologies.1 As detailed in TCGA’s integrated genomic characterization of cervical cancer (ie, squamous, adenocarcinoma, and adenosquamous histologies), mutations in the PIK3CA gene were the most frequently identified aberration, occurring in 26% of samples, approximating the nearly 20% rate in our cohort.