The prevalences of ALK and FGFR3 fusions were significantly higher in this ctDNA cohort compared with a previously reported cohort of 4,422 CRC tissue specimens undergoing comprehensive NGS genomic profiling (P = .04, P = .01, respectively).There was no difference in frequencies of RET or NTRK fusions between ctDNA and tissue assays (Fig 1C; Table 1).28 This evidence concerns the gene RET and colorectal carcinoma.