In triple-negative breast cancer (TNBC), which is considered the most challenging breast tumor, increased CD47 expression was significantly associated with an advanced tumor-node-metastasis stage, lymph node involvement, and recurrence; authors also concluded that CD47 was an unfavorable and independent prognostic factor for 5-year disease-free survival in patients with TNBC [25]. The gene discussed is CD47; the disease is triple-negative breast carcinoma.