Recently, an in vitro study presented by Nigro et al. demonstrated that CD47 expression became upregulated in EGFR mutated NSCLC cell lines following the development of resistance to Gefitinib and blocking of CD47 by a specific mAb increased the clearance of EGFR-TKI resistant cells by phagocytes. This evidence concerns the gene EGFR and non-small cell lung carcinoma.