The function of NLRP3 during tumorigenesis is still controversial, while some studies evidenced its protective role, and others came to the conclusion that its action has destructive outcomes, whereas, in head and neck cancer [72], the activation of cryopyrin leads to tumor outgrowth, and in colitis-associated tumor, secretion of IL-18 via NLRP3 delivered protection against malignant tissue development [73]. The gene discussed is IL18; the disease is neoplasm.