The top 10 nodes, including miR-144-3p, miR-363-3p, miR-9-3p, miR-21-3p, miR-144-5p, miR-338-3p, miR-770-5p, ID4, PIK3R1, and FN1, were selected as hub nodes in the development of DCM. This evidence concerns the gene PIK3R1 and familial dilated cardiomyopathy.