To assess the strength of the miRNA-mRNA network analysis, we filtered 10 mRNAs and genes including miR-144-3p, miR-144-5p, miR-9-3p, miR-363-3p, miR-338-3p, miR-770-5p, miR-21-3p, ID4, PIK3R1, and FN1, which are believed to play critical roles in the development and pathological mechanisms of DCM. This evidence concerns the gene PIK3R1 and familial dilated cardiomyopathy.