Interestingly, further work showed that CD147 drastically increased MCT4 mRNA level in CaCO2 of IECs; in line with this, the results showed that overexpression of CD147 enhanced MCT4 expression, while inhibition of CD147 significantly reduced MCT4 expression in HT-29 and CaCO2 cells (Figures 2(a) and 2(b)), implying involvement of CD147 in IBD in a MCT4-dependent way, which is consistent with the results that revealed that silencing either MCT1 or MCT4 in ARPE-19 cells resulted in decreased expression of their accessory subunit, CD147 [16, 17]. This evidence concerns the gene BSG and inflammatory bowel disease.