In liver cancer cells, TM4SF1 promoted growth and inhibited apoptosis (Huang et al., 2016; Zhu C. et al., 2019); overexpression of TM4SF1 reduced apoptosis in vitro and increased proliferation in vivo, while decreased expression had the opposite effects (Huang et al., 2016). The gene discussed is TM4SF1; the disease is liver cancer.