TM4SF1 and diabetes mellitus: Xu D. et al. (2020) showed that elevated expression levels of TM4SF1 and advanced clinicopathological features are associated with poor prognosis in pancreatic cancer patients. TM4SF1 expression was related to tobacco smoking, tumor size, diabetes, clinical stage, T stage, lymph node metastasis, tumor cell venous invasion, distant tumor metastasis, lymphatic invasion, and poor overall survival in patients with pancreatic cancer (Xu D. et al., 2020).