TM4SF5 recruits with different actin-organizing molecules including neuronal Wiskotte, Aldrich Syndrome protein (N-WASP), actin-related protein 2 (Arp2) in invadopodia to promote migration/invasion of HCC (Lee et al., 2011; Jung et al., 2012; Lee, 2015). Here, TM4SF5 is linked to hepatocellular carcinoma.