By using chimeric constructs, Jin-Gyu Cheong et al. reported that the C-terminus of TM4SF5 played an important role to regulate the diverse metastatic functions, and could positively replace the C-termini of TM4SF1 or TM4SF4, which increased the ability of cancer cell proliferation migration, and invasion (Cheong et al., 2017). Here, TM4SF1 is linked to cancer.