Dysregulation of the cell cycle and ROS homeostasis in bladder cancer induced by silencing of TM4SF1 may involve the peroxisome proliferator-activated receptor (PPAR)-sirtuin1 (SIRT1) feedback loop, because crosstalk between SIRT1 and PPARγ plays a significant role in the modulation of apoptosis, antioxidant responses, and the cell cycle (Cao et al., 2018). This evidence concerns the gene SIRT1 and urinary bladder cancer.