A conjugate consisting of 2A7A, a humanized TM4SF1 mAb, and the auristatin cytotoxic agent LP2 (chemical name mc-3377) damaged the ECs in the mouse tumor vasculature and inhibited the growth of several tumor xenografts with dosage-related toxicity (Visintin et al., 2015). This evidence concerns the gene TM4SF1 and neoplasm.