Oral submucous fibrosis (OSF) is a potentially malignant tumor, and in OSF, miR-203 promotes EMT by targeting TM4SF1 and downregulating the expression of CK19 and E-cadherin while upregulating the expression of N-cadherin and vimentin (Zheng L. et al., 2015). This evidence concerns the gene TM4SF1 and neoplasm.