GCLCh/h mice with a hepatocyte-specific ablation of GCLC developed severe steatosis, although with L-N-acetylcysteine treatment, GCLCh/h mice also display characteristics of fibrosis at age 50 days, and even macronodular cirrhosis at age 120 days (Chen et al., 2010). The gene discussed is GCLC; the disease is Cirrhosis.