GCLC and Hepatic fibrosis: GCLC, known as an important antioxidative gene (Ramani et al., 2012), was verified dramatically decreased in plasma and liver tissue of patients with HCV-related liver fibrosis, and also it was down-regulated in activated HSC induced by conditioned medium from HCV core stably expressed cell lines, LO2-CORE and HepG2-CORE.