In our study, we first found that GCLC was dramatically downregulated in plasma and liver tissues of patients with HCV-related liver fibrosis and activated HSC induced by conditioned medium from LO2-core and HepG2-core cells, which indicated that GCLC negatively regulated the progression of HCV-induced liver fibrosis and the activation of HSC. The gene discussed is GCLC; the disease is Hepatic fibrosis.