The top 10 differentially genes were zinc finger C3H1-type containing (ZFC3H1), GCLC, secreted LY6/PLAUR domain containing 1 (SLURP1), guanylate kinase 1 (GUK1), isocitrate dehydrogenase 3 [NAD(+)] gamma (IDH3G), ubiquitin conjugating enzyme E2 H (UBE2H), transmembrane channel like 5 (TMC5), secretory carrier membrane protein 3 (SCAMP3), 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), and C-X9-C motif containing 1 (CMC1) (Figure 1D), and GCLC as the antioxidative gene might participate in the pathogenesis of HCV-related liver fibrosis. This evidence concerns the gene GUK1 and Hepatic fibrosis.