ESR1 and breast cancer: To this end, Szarc Vel Szic et al. (111) showed that withaferin A (WA), a steroidal lactone, commonly known as Ashwagandha, Indian ginseng or Indian winter cherry, downregulated HER2/PR/ESR-dependent gene expression interactions and repressed aggressive triple-negative MDA-MB-231 BC cells with a specific DNA hypermethylation profile of tumor oncogenes.