IGHE and allergic asthma: Allergic asthma is a chronic airway inflammation, which would cause activation of CD4+ T cell, eosinophils, and IgE-producing B cells, polarize T helper (Th)2 cells, as well as induce Th2 cytokines (such as IL-4, IL-5, IL-13) and secretion of other cytokines (IL-17, IL-33, IL-25) (76, 77).