The potential role of ferroptosis in mediating renal damage in SLE awaits further study; given evidence of impaired anti-oxidant defenses, including reduced levels of the key anti-ferroptotic enzyme glutathione peroxidase 4 in the kidneys of MRL/lpr mice (42), this seems an intriguing avenue of investigation. This evidence concerns the gene GPX4 and systemic lupus erythematosus.