In order to validate the reported data on IgG in pemphigus in a larger cohort, as well as to fill the knowledge gap regarding other Ig classes and pemphigoid diseases, we here contrasted the serum concentrations of total IgG, IgG1–4, IgA, and IgM in PV, PF, as well as the pemphigoid diseases bullous pemphigoid (BP) and linear IgA bullous dermatosis (LAD), to those in healthy controls. The gene discussed is CD40LG; the disease is pemphigus.