Zhuang et al. found that the Von Hippel-Lindau (VHL) -deficient cells expressing FTO might restore mitochondrial activity, induce oxidative stress and ROS production and suppressed tumor growth, via promoting PGC-1α expression by decreasing m6A levels in its mRNA transcripts (Zhuang C. et al., 2019). Here, PPARGC1A is linked to neoplasm.