SOX2 and neoplasm: For example, in HCC, sumo1 modification of METTL3 can promote tumor progression via regulating snail mRNA homeostasis (Xu et al., 2020), while in glioblastoma, LncRNA SOX2OT can facilitate temozolomide resistance through promoting SOX2 expression via ALKBH5-mediated epigenetic regulation (Liu X. et al., 2020).