PPARGC1A and renal cell carcinoma: Zhuang C. et al. (2019) found that PGC-1α underwent m6A methylation in RCC. As an m6A demethylase, FTO could recognize the m6A sites of PGC-1α and reduce its methylation level, therefore leading to the increases in mitochondria biogenesis and oxidative phosphorylation and the decreases in tumor growth of RCC (Zhuang C. et al., 2019).