Besides the described ability to act as an anti-cancer drug, RNase1 is also suggested to operate as a tumor marker for pancreatic cancer, since tumor cells and cancer-associated ECs secreted a differently glycosylated form of RNase1 compared to healthy cells (Peracaula et al., 2003; Barrabes et al., 2007). This evidence concerns the gene RNASE1 and familial pancreatic carcinoma.