CREBBP and diffuse large B-cell lymphoma: In folicullar lymphoma (FL) and diffuse large B cell lymphoma (DLBCL), however, CREBBP mutations lead to unopposed deacetylation by BCL6-SMRT-HDAC3 at an enhancer of B cell signal transduction and expression of immune response genes, which results in lymphomagenesis (Pasqualucci et al., 2011; Jiang et al., 2017).