PTHLH and lymphoid neoplasm: Additionally, malignancy is also a common cause for disorders of calcium and phosphorus metabolism via direct invasion of bone in Local Osteolytic Hypercalcemia (LOH), enhancing the flow of parathyroid hormone-related protein (PTHrP), which has the similar function with PTH, or increased synthesis of 1,25(OH)2D in various lymphoid tumors (Guise et al., 1996).